IndraLab

Statements

COPS6 increases the amount of CTNNB1. 7 / 8
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"In line with this finding, western blotting revealed that knockdown of CSN6 by shRNA decreased the expression of beta-catenin and increased the expression of beta-Trcp."
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"CSN6 positively regulates beta-catenin expression in a beta-Trcp-dependent manner and triggers the expression of several EMT related genes regulated by beta-catenin."
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"CSN6 increased the steady-state expression of beta-catenin in a dose dependent manner while downregulating beta-Trcp (XREF_FIG)."
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"CSN6 positively regulated beta-catenin expression in a beta-Trcp-dependent manner and triggered expression of several EMT related genes regulated by beta-catenin."
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"CSN6 positively regulates beta-catenin expression."
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"CSN6 increased the steady-state expression of beta-catenin in a dose dependent manner while downregulating beta-Trcp."
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"Together, the results suggest that CSN6 may positively regulate beta-catenin transcription, thereby mediating the EMT."
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