IndraLab

Statements

reach
"Given that USP26 and USP37 are able to reverse RNF8/168 mediated ubiquitylation and promote HR, these enzymes would be ideal candidates to facilitate the repositioning of ubiquitylated substrates away from the DSB."
26101254
reach
"Interestingly, in contrast with initial findings assessing overexpression of these DUBs, knockdown of either USP26 or USP37 impairs accumulation of key HR factors including RAD51 as well as PALB2, CtIP, and RPA [154]."
32708614
reach
"A striking conclusion from our study is that both over-expression as well as knockdown of USP26 or USP37 impairs HR."
26101254
reach
"Loss of USP26 and USP37 function markedly impairs the assembly of PALB2, RAD51 and efficient HR."
26101254
reach
"Loss of USP26 or USP37 impairs HR by counteracting RAP80 dependent sequestration of BRCA1."
26101254