IndraLab
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EIF3F inhibits apoptotic process. 12 / 13
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"In our current study, we tested the hypothesis that eIF3f coordinates with hnRNP K to regulate rRNA degradation and that decreased eIF3f expression contributes to tumorigenesis by deregulating translation and apoptosis."
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"These results show that eIF3f silencing affects cell viability and induces apoptosis in A549 cells."
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"Loss of eIF3f in pancreatic cancer may contribute to tumor cells ' evading apoptosis via upregulation of protein synthesis."
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"EIF3f knockdown in A549 cells was shown to inhibit cell proliferation and induce apoptosis."
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"The same group found that eIF3f overexpression in cancer cells negatively regulates cell growth by affecting the translation efficiency and the activation of apoptosis (Shi et al., 2006)."
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"As predicted, eIF3f SATA mutant did attenuate apoptosis in CDK11 p46 overexpressing cells compared to wild type eIF3f (XREF_FIG)."
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"Endogenous eIF3f silencing by antisense RNA or siRNA inhibits cell growth and induces apoptosis in A549 cancer cells."
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"Likewise, eIF3f knockdown in normal human pancreatic epithelial cells has shown an increase in cell proliferation and increased resistance to apoptosis [109]."
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"Increased expression of eIF3f reduces cellular growth by inducing apoptosis in melanoma and pancreatic cancer cells [XREF_BIBR - XREF_BIBR]."
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"To examine whether eIF3f SATA mutant attenuates apoptosis in CDK11 p46 overexpressing cells, we co-transfected CDK11 p46 with wild type or mutant eIF3f followed by apoptosis assay."
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"Knockdown of endogenous eIF3f by siRNA attenuates apoptosis in melanoma cells after treatment with staurosporine as apoptotic agent [XREF_BIBR]."
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"The same group found that eIF3f overexpression in cancer cells negatively regulates cell growth by affecting the translation efficiency and the activation of apoptosis."