IndraLab

Statements


SCN2A activates PRNP. 3 / 3
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"One compound, termed Compound B (CmpdB) (XREF_FIG), had cellular EC 50 values of 60 pM in ScN2a cells and ~ 300 muM in two ScN2a cell lines overexpressing PrP."

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"These results support that expression of shRNA suppressed PrP C expression.To test whether expression of shRNA targeting prnp inhibits PrP Sc formation, ScN2a cells were transfected with pShRNA-PrPT."

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"ScN2a and ScHaB cells in culture produce several PrP molecules with relative molecular masses of 26-35 kDa and proteinase K resistant cores of 19-29 kDa."