IndraLab

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"Finally, Western blotting experiments, Transwell migration assays, and wound healing assays indicated that OTUB2 knockdown reduced EMT and migration ability of colon cancer cells, which could be restored by GINS1 overexpression."
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"Additionally, Western blotting assays along with Transwell migration assays and wound healing assays verified that EMT process as well as migration ability in colon cancer cells were suppressed by OTUB2 knockdown but could be rescued through SP1 overexpression, and vice versa (Fig. S8C-E)."
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"These results indicate that OTUB2-regulated expression of ZEB1 enhances EMT to promote invasion and metastasis in iCCA cells ( Fig. 4 E and F)."
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"OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression."
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