IndraLab

Statements

Val-Ala inhibits NLRP3. 4 / 4
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"Conversely, a synthetic VA RNAI molecule was able to inhibit the NLRP3 inflammasome activation in the absence of an HAdV infection."
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"Since VA RNAI blocks NLRP3 inflammasome activation, this knowledge may help to design sncRNA based therapeutics against overactivation of the inflammasome [XREF_BIBR]."
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"An Ad5 mutant virus defective in expression of the non coding VA RNAI failed to inhibit the NLRP3 inflammasome and in addition displayed formation of ASC specks and increased cell lysis."
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"Moreover, since inflammation is such a central part of a virus infection, the recent finding that VA RNAI blocks NLRP3 inflammasome activation [XREF_BIBR], urges for more detailed studies about the anti-inflammatory role of VA RNAI and potentially of VA RNAII."
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