IndraLab

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Val-Ala inhibits NLRP3. 7 / 7
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"Moreover, since inflammation is such a central part of a virus infection, the recent finding that VA RNAI blocks NLRP3 inflammasome activation [XREF_BIBR], urges for more detailed studies about the anti-inflammatory role of VA RNAI and potentially of VA RNAII."
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"Since VA RNAI blocks NLRP3 inflammasome activation, this knowledge may help to design sncRNA based therapeutics against overactivation of the inflammasome [63]."
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"Moreover, since inflammation is such a central part of a virus infection, the recent finding that VA RNAI blocks NLRP3 inflammasome activation [63], urges for more detailed studies about the anti-inflammatory role of VA RNAI and potentially of VA RNAII.Limited data is available about the mivaRNA function during HAdV infection."
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"Conversely, a synthetic VA RNAI molecule was able to inhibit the NLRP3 inflammasome activation in the absence of an HAdV infection.Mechanistically, the capacity of VA RNAI to block PKR activation seems to be caused by the inhibitory effect of VA RNAI on PKR activity since the disruption of base pairing within the conserved tetranucleotide GGGU-ACCC stem blocked VA RNAI as an inhibitor of inflammasome activation [63]."
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"Conversely, a synthetic VA RNAI molecule was able to inhibit the NLRP3 inflammasome activation in the absence of an HAdV infection."
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"Since VA RNAI blocks NLRP3 inflammasome activation, this knowledge may help to design sncRNA based therapeutics against overactivation of the inflammasome [XREF_BIBR]."
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"An Ad5 mutant virus defective in expression of the non coding VA RNAI failed to inhibit the NLRP3 inflammasome and in addition displayed formation of ASC specks and increased cell lysis."
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