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Nefazodone inhibits KCNH2. 7 / 12
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"Our previous studies demonstrated that nefazodone blocks hERG channels, which might explain the cardiac toxicity of nefazodone ( Shin et al., 2014 )."
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"However, nefazodone induced hERG inhibition indicated only a theoretical risk of cardiotoxicity."
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"Nefazodone inhibited hERG channel activity in our system."
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"Nefazodone inhibited the hERG channel in a concentration dependent manner with an IC50 of 45.3 nM in HEK-293 cells."
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"Nefazodone inhibited I Kr with an IC 50 value of 41.4 ± 0.2 nM ( Fig. 5 B) and blocked hERG completely at a dose of 100 nM ( Fig. 5 D)."
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"We have recently found that nefazodone inhibits human ether-a-go-go related gene (hERG, KCNH2 or Kv11.1) channels by interacting with the aromatic binding sites Y652 and F656 within the S6 domain of h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A novel assessment of nefazodone induced hERG inhibition by electrophysiological and stereochemical method."
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