IndraLab

Statements

reach
"AA inhibits the NLRP3 inflammasome."
38265935
reach
"Additionally, Milton Pereira et al. found that AA inhibited NLRP3 inflammasome activity in both human and mouse macrophages, which in turn reduced the production of pro-inflammatory cytokines IL-1β and IL-18 [31]."
40057623
reach
"It is concluded that AA inhibits inflammation and oxidative stress by activating Nrf2 and HO-1 and inhibiting ROS and NLRP3 inflammasome pathways to achieve the purpose of inhibiting SCI (Jiang et al., 2016)."
35754957
reach
"LCA, however, does not affect PKC, PKD, and JNK phosphorylation, suggesting that AA and bile salts inhibit the NLRP3 inflammasome by distinct mechanisms (Figures 7A–7D)."
38265935
reach
"Here, we show that AA inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1β production under physiological conditions."
38265935
reach
"If AA inhibits NLRP3, then ASC speck formation, as well as IL-1β production, is expected to be reduced."
38265935
reach
"Unexpectedly, we showed in vitro that AA itself inhibits activation of the NLRP3 inflammasome, while AA metabolites do not."
38265935
reach
"COX inhibitors, which decrease the production of AA eicosanoid metabolites, but not AA itself, also decrease NLRP3 activity, providing further evidence that the NLRP3-inhibitory effect is a direct result of AA rather than a metabolite.We hypothesized that AA-driven NLRP3 inhibition might occur by product inhibition of the enzymes that liberate AA from the plasma membrane, which are PLA - and, to a lesser extent, PLC dependent."
38265935
reach
"We speculate that a similar GSDMD pore repair process may explain our observations, although the relationships between AA, ESCRT III, and NLRP3 remain to be elucidated.Our work demonstrates a mechanism by which the NSAID COX inhibitors have broad anti-inflammatory effects: through AA inhibition of NLRP3 activity."
38265935
reach
"125 This inhibitory effect on inflammasome activation is also mimicked by arachidonic acid which inhibited the NLRP3 inflammasome by reducing JNK activation."
39327931
reach
"Mechanistically, AA inhibits phospholipase C activity to reduce JNK1 stimulation and hence NLRP3 activity."
38265935
reach
"Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting."
38265935
reach
"It has been shown that fasting increases blood levels of arachidonic acid, which in turn reduces the activity of the NLRP3 inflammasome, thereby suppressing inflammation [19]."
39972454
reach
"AA inhibits NLRP3 inflammasome activity in human and mouse macrophages."
38265935
reach
"AA inhibited TGF-β1, NF-κB, myeloid differentiation factor-88, complement, Smad3, NLRP3 inflammasome, and induces Smad7 and nerve growth factors."
30233358