IndraLab

Statements

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"Inhibition of PPARgamma abolishes the protective effects of AA against I/R induced inflammatory injury and NLRP3 inflammasome activation."
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"Administration of AA significantly attenuated hepatic histopathological damage, global inflammatory level, apoptotic signaling level, as well as NLRP3 inflammasome activation."
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"PPARgamma/ROS/MAPK and PPARgamma/ROS/NF-kappaB involve in AA mediated suppression of NLRP3 inflammasome."
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"These findings were also confirmed by in vitro experiments in which AA pretreatment suppressed NLRP3 activation in LPS/H 2 O 2 -challenged KCs or RAW264.7 cells."
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"Therefore, AA attenuated NLRP3 signaling both at expression level and assembly level."
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"Administration of AA significantly suppressed NLRP3 activation and global inflammatory levels in the ischemic liver."
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"AA decreases NLRP3 inflammasome activation in ischemic liver."
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"Furthermore, GW9662 reversed AA mediated suppression of NLRP3 signaling, as evidenced by increase in mRNA levels of NLRP3 and IL-1beta, protein levels of NLRP3 and pro-IL-1beta, formation of NLRP3, ASC, pro, and caspase-1 complex as well as production of cleaved capase-1 p10 and mature IL-1beta."
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"Emerging evidence demonstrates that AA inhibits NLRP3 inflammasome assembling and caspase-1 inhibition in macrophage [XREF_BIBR]."
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"AA inhibited TGF-β1, NF-κB, myeloid differentiation factor-88, complement, Smad3, NLRP3 inflammasome, and induces Smad7 and nerve growth factors."
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