IndraLab

Statements

USP7 increases the amount of MDM2. 8 / 8
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"As shown in XREF_FIG, knockdown of USP7 reduced the levels of Mdm2 and p53, a result consistent with that of a previous study."
28406480
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"Inhibition of USP7 decreases Mdm2 levels resulting in a corresponding increase in p53, inducing apoptosis."
30528168
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"As shown by the Gu group, partial reduction of USP7 levels in several human cell lines promotes decreased levels of both MDM2 and p53, yet total abolition of USP7 stabilizes p53 levels by decreasing MDM2 [117, 118]."
24239534
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"Thus, HAUSP-mediated de-ubiquitination can bring about increased levels of MDM2 that then accelerate p53 degradation to directly reduce the level of p53."
32532965
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"Moreover, while the levels of Mdm2 were enhanced by USP7 co-transfection, Mdm2 mediated Poleta degradation was indeed strongly rescued by USP7 overexpression (XREF_FIG)."
25435364
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"USP7 silencing by siRNA reduces chromatin accessibility and repair by modulating Mdm2 levels."
21138959
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"USP7 (ubiquitin specific protease 7), which deubiquitinates HDM2, can lead to increased levels of HDM2 and decreased levels of p53."
22649774
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"In fact, we found that HAUSP silencing in SAMe-D cells induced a decrease in Mdm2 levels (XREF_FIG), the major substrate stabilized by HAUSP, and an increase in nuclear localization of p53 after UVC treatment (XREF_FIG left panel)."
20815019