IndraLab

Statements

PRPF8 activates Hypoxia. 3 / 3
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"CCK8 results revealed that transfection with PRP8 siRNA reversed hypoxia‐induced HPASMC proliferation, and this effect was eliminated after silencing circNAP1L4 (Figure 6E)."
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"Importantly, our results also showed that PRP8 siRNA reversed hypoxia‐induced HPASMC glycolysis and proliferation, suggesting that PH might be due in part to the aberrant NAP1L4 pre‐mRNA splicing caused by PRP8 in PASMCs."
39102213
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"These data suggest that PRPF8 supports hypoxia-induced mitochondrial clearance by ensuring correct ULK1 splicing, also with a likely effect on general autophagy, suggested by a global effect on autoph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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