IndraLab

Statements

USP22 increases the amount of ITGB1. 5 / 5
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"Therefore, USP22 controls breast cancer stem cell self-renewal through protecting FoxM1 from ubiquitination-mediated proteasomal degradation to enhance ITGB1 transcription."
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"The fact that USP22 deletion reduced ITGB1 mRNA expression suggest that USP22 regulates integrin b1 expression at transcriptional level."
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"Therefore, USP22 controls BCSCs self-renewal through protecting FoxM1 from ubiquitination-mediated proteasomal degradation to enhance ITGB1 transcription."
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"The fact that USP22 deletion reduced ITGB1 mRNA expression suggests that USP22 regulates integrin β1 expression at the transcriptional level."
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"This further corroborates our discovery that upregulation of USP22 in BCSCs promotes breast cancer lung metastasis through FoxM1-mediated ITGB1 gene transcription."
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