IndraLab

Statements

ENO1 binds TLR4. 16 / 18
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"These well-documented data led us to evaluate the binding of ENO1 to TLR4."
27025255
sparser
"These results suggest that ENO1 binds TLR4 but not in the same manner as LPS."
27025255
sparser
"Co-IP assays using shENO1 cells confirmed the interaction between ENO1 and TLR4 in GBM cells, with diminished binding upon ENO1 knockdown (Fig. xref )."
41353343
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"These findings collectively establish cell membranous ENO1-TLR4 receptor interaction as a critical axis in GBM progression."
41353343
sparser
"While prior studies have established that ENO1 binds TLR4 on GBM cells to regulate malignancy, its downstream signaling cascades remained unexplored."
41353343
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"This observation suggests that citrullination does not alter ENO1 binding to TLR4 or subsequent inflammatory response, while a loss of function has been reported for other proteins such as MBP-1 in multiple sclerosis XREF_BIBR."
27025255
reach
"Further to our present results that show ENO1 binding to TLR4, it would be interesting to study the direct interaction of ENO1 TLR4 and CD14 by surface plasmon resonance technology for better understanding of ENO1 action and to highlight the specific pathways involved."
27025255
sparser
"Further to our present results that show ENO1 binding to TLR4, it would be interesting to study the direct interaction of ENO1 TLR4 and CD14 by surface plasmon resonance technology for better understanding of ENO1 action and to highlight the specific pathways involved."
27025255
sparser
"Our investigation further identified a direct interaction between ENO1 and TLR4 on GBM cells mediated by hydrogen bonding, consistent with prior reports of ENO1-TLR4 signaling in immune activation [ xref ]."
41353343
sparser
"Our study mechanistically linked ENO1-TLR4 signaling to SPHK1 activation and S1P production, with TLR4/SPHK1 inhibitors (TAK-242/PF-543) blocking this axis."
41353343
reach
"These results suggest that ENO1 binds TLR4 to induce a pro inflammatory response."
27025255
sparser
"First, although we confirmed the ENO1-TLR4 interaction in GBM, the precise binding sites remain undefined and require further investigation."
41353343
reach
"These results suggest that ENO1 binds TLR4 but not in the same manner as LPS."
27025255
reach
"These well documented data led us to evaluate the binding of ENO1 to TLR4."
27025255
sparser
"These results suggest that ENO1 binds TLR4 to induce a pro-inflammatory response."
27025255
sparser
"In order to compare the binding of ENO1 and LPS to TLR4, we performed a competitive binding assay with ENO1 and FITC-labelled LPS using HEK-Blue hTLR4 cells."
27025255