IndraLab

Statements

TNFAIP3 activates MYD88-L265P. 2 / 2
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reach
"The lack of any measurable effect of CD79B in these assays contrasts with our previous findings, in which loss-of-function mutations in Tnfaip3 (A20) blocked MYD88 L265P -induced down-regulation of CD23, CD25, CD86, and CD95."
28701369
reach
"Overall, these results suggest that MYD88 L265P signaling can be enhanced by a second genetic alteration in TNFAIP3 and highlights a potential opportunity for therapeutic targeting."
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