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USP2 activates LEF1. 4 / 4

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"Next, we identified whether USP2 can modulate LEF1 in a deubiquitination way."

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"Mechanistically, our findings indicate that USP2 promotes the stability of LEF1 through deubiquitination, thereby preventing its degradation."

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"USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells."

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"USP2 promotes LEF1 protein stability by deubiquitination."

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USP2 activates LEF1. 4 / 4

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