IndraLab

Statements

USP18 activates DENV-2. 3 / 3
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"USP18 overexpression promoted DENV-2 replication, while USP18 silence inhibited DENV-2 replication."
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"Ye et al. (2021) demonstrated that DENV-2 infection increased USP18 expression; USP18 overexpression enhanced DENV-2 replication, while USP18 silencing inhibited DENV-2 replication by activating the IFN-α-mediated JAK/STAT signaling pathway."
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"Overexpression of USP18 promoted DENV-2 replication, while its silencing abrogated the replication and increased the anti-DENV-2 specific IFN-α through the activation of the IFN-α-mediated Jak/STAT signaling pathway, as shown by the increased expression of p-STAT1/p-STAT2 and the elevated expression of some ISGs."
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