IndraLab

Statements

UCHL3 activates glioblastoma multiforme cancer stem cell. 3 / 3
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"UCHL3 promotes GSC progression and IR resistance via POLD4."
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"At the molecular level, under IR exposure UCHL3 knockdown reduced the protein expression of well-known MES GSC markers (CD44, TAZ, etc.), and POLD4 overexpression restored the expression of these markers (Fig. 6H)."
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"Regulating biological functions, UCHL3 promoted GSC proliferation, tumorigenesis, self-renewal, and radioresistance in a POLD4-dependent manner.The degradation of POLD4 by ubiquitin ligases in response to DNA damage and during cell cycle progression plays a less prominent role in normal cells [43], while with increasing insights into the complex mechanisms of DNA damage repair, POLD4 is projected to play an increasingly important role."
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