IndraLab

Statements

USP4 inhibits IRF3. 5 / 5
| 5
reach
"As shown in Fig. 5 A and B, the knockdown of USP4 dramatically increased the nuclear accumulation of IRF3."
38556105
reach
"Western blot analysis also revealed that knockdown of USP4 facilitated the translocation of IRF3 to the nucleus, whereas overexpression of USP4 impeded the nuclear translocation of IRF3 ( Figs."
38556105
reach
"These results suggest that USP4 suppresses IRF3 activation, probably indirectly through the deubiquitination of IRF3."
38556105
reach
"Overall, these data suggest that USP4 suppresses IRF3 activation and the IFN response, at least partially, by deubiquitinating the K63-linked polyubiquitination of IRF3 either through TRAF6 or by dire[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38556105
reach
"Moreover, IHC staining in MC38 tumors confirmed the in vitro data that USP4 suppressed the nuclear accumulation of IRF3 ( Fig. S5A )."
38556105