IndraLab

Statements

USP13 inhibits MYC. 2 / 3
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"USP13, FBXL14 and c-Myc can interact with each other; USP13 inhibits the degradation of c-Myc, hence inhibition of USP13 promotes the apoptosis of glioma stem cells."
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"Moreover, treatment with a proteasome inhibitor blocked the c-Myc loss caused by USP13 knockdown (not depicted), but overexpression of USP13 delayed c-Myc turnover in the presence of cycloheximide (not depicted), suggesting a critical role of USP13 in preventing proteasomal degradation of c-Myc in GSCs."
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