IndraLab

Statements

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"BITC treatment led to decrease in NF-kappaB transcriptional activity and kappaB-DNA binding of p65 in BITC treated pancreatic cancer cell lines, BxPC-3 and Capan-2 cells, while decreasing NF-kappaB and p65 phosphorylation at Ser536."
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"Inactivation of NF-kappaB and p65 by BITC in pancreatic cancer cells."
20484017
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"Thus, BITC may be of limited use as a chemotherapeutic agent on its own, but it also has the potential to reduce the efficacy of other drugs in combination treatments due to its activation of the PI3K/Akt/FoxO pathway.Abe et al. found that 10 µM BITC inhibits proliferation by activating p65."
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