IndraLab

Statements

COPS6 activates cell cycle. 4 / 4
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"We demonstrated that COPS6 and COPS9 promote cell cycle progression, but it is unknown whether these effects are dependent on p21 and p18 degradation via a ubiquitin-mediated process."
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"Taken together, these data demonstrated that CSN6 could promote cell cycle progression in GC cells."
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"To explore the molecular mechanism underlying CSN6-induced cell cycle progression, we measured the expression of some G1 cell cycle regulatory proteins."
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"This study revealed that CSN6 knockdown in melanoma cells inhibited cell proliferation in vitro and tumorigenicity in mice by inducing cell cycle arrest and that the anti-proliferative effect could be rescued by overexpressing CSN6 in CSN6-knockdown melanoma cells, suggesting that CSN6 has critical roles in triggering melanoma initiation and progression."
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