IndraLab

Statements

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"It has been proposed that the differential selectivity of DTX-K, which exclusively blocks Kv1.1 channels, compared to αDTX, which inhibits Kv1.1, 1.2, and 1.6 channels, may be attributed to the presence of two critical residue regions in DTX-K (located in the β-hairpin and the 3 -helix), as opposed to only one region in αDTX (located at the N-terminus and not the β-hairpin)."
38251229
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"In fact, the abnormal conductivity in demyelinated axons were nearly normalized by attenuating the Kv1.1-mediated currents with the available selective blocker (DTX K ) of Kv1.1 homotetramers [16] ."
32428746
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"Dendrotoxin-K (DTX-K) from the mamba snake venom blocks both Kv1.1 and Kv1.2 with K ~ 0.6 nM and ~ 9.6 nM, respectively (35, 36)."
38102952
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"In voltage-clamp experiments, dendrotoxin-K (DTX-K), a Kv1.1-specific inhibitor, significantly reduced peak outward K + currents in wildtype (WT) atrial cells but not Kcna1 -/- cells, demonstrating an important contribution by Kv1.1-containing channels to mouse atrial repolarizing currents."
30427720