IndraLab

Statements


COPS5 increases the amount of HIF1A. 3 / 4
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"Interestingly, Jab1 and CSN5 was shown to interact directly with HIF-1a and increased HIF-1a protein levels in hypoxia [9]."

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"Furthermore, Jab1 increased HIF-1alpha protein levels, which was due to the enhanced HIF-1alpha stability."

"Moreover, Jab1-enhanced transcriptional activity of HIF-1 under hypoxia led to increase the expression of VEGF, a major HIF-1 target gene. Furthermore, Jab1 increased HIF-1alpha protein levels, which was due to the enhanced HIF-1alpha stability"