IndraLab

Statements

MINK1 binds KCNH2. 6 / 6
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"It is already known, for example, that minK can interact with KVLQT1 and HERG when overexpressed in heterologeous systems (McDonald et al., 1997)."
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"10 Thus, minK interacts with both KCNQ1 and HERG, and KCNE1-3 proteins interact with Kv3.1 and Kv3.2 causing diversification of channel gating."
18313602
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"Herg, a human homologue of the ether-a-go-go gene of the fruitfly drosophila melanogaster, encodes aproteinthat produces the rapidly activating cardiac delayed rectifier (i[kr]). / our results show that mink physically associates with herg and that the interaction leads to increased ikr current density."
9230439
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"Alanine at codon 8 is next to threonine at 7 7 and caused a significant modulation on the MinK and HERG complex."
17341399
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"Thus, minK and MiRP1 interaction with HERG are not mediators of regulators of the kinase dependent enhancement of channel synthesis."
22613764
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"A minK and HERG complex regulates the cardiac potassium current I (Kr)."
9230439