IndraLab

Statements

USP28 binds KDM1A. 21 / 26
5 | 10 11
sparser
"Together, these data indicate that USP28 interacts with LSD1 and this interaction is mediated through the AO domain of LSD1 and N-terminal region of USP28."
24075993
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"To examine whether interaction of HDAC5 with LSD1 and USP28 complex deacetylates LSD1 or USP28, in vitro protein acetylation assays was first carried out by incubating GST tagged recombinant HDAC5 protein with cellular pull-down of LSD1-FLAG or USP28-FLAG by IP, and immunoprecipitates of IgG was incubated with recombinant HDAC5 protein as negative control of assays (XREF_FIG)."
27212032
sparser
"Additionally, the level and activity of the histone demethylase lysine specific demethylase 1 (LSD1) can be controlled by USP28 through a deubiquitination event, during which an amine oxidase domain in LSD1 and the N-terminal region of USP28 are responsible for the LSD1 interaction with USP28 [ xref ]."
36879346
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"To investigate whether USP28 interacted with LSD1, we co-expressed Flag-LSD1 and HA-USP28 in HEK293 cells."
24075993
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"The interaction between LSD1 and USP28 is specific, as LSD1 could not interact with USP7 and USP25 under similar conditions (XREF_SUPPLEMENTARY)."
24075993
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"Different from the interaction of USP28 with LSD1, USP28-mediated p53BP1 stabilization only occurs after DNA damage and no effect is found in the absence of DNA damage, suggesting that the interaction between USP28 with p53BP1 is regulated by DNA damaging."
24075993
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"Together, these data indicate that USP28 interacts with LSD1 and this interaction is mediated through the AO domain of LSD1 and N-terminal region of USP28."
24075993
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"In this study, we found that USP28 interacted with and stabilized LSD1 from ubiquitination."
24075993
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"In our study, we found that knockdown of Myc did not affect the binding between USP28 and LSD1 (XREF_SUPPLEMENTARY)."
24075993
sparser
"USP28 interacts with LSD1."
24075993
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"USP28 interacts and deubiquitylates LSD1, and the expression levels of the two proteins correlate well in tumor cell lines and tumor samples."
27516771
sparser
"Wu et al. showed that the USP28-LSD1 axis in b-CSCS led to enhanced self-renewal and mammosphere formation in vitro, as well as increased tumor growth in vivo [ xref ]."
31756917
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"Accordingly, the USP28-LSD1 axis can play a vital role in the protection of CSC characteristics [ xref ]."
36879346
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"USP28 interacted with and stabilized LSD1 via deubiquitination."
24075993
reach
"USP28 interacts with LSD1."
24075993
sparser
"To investigate whether USP28 interacted with LSD1, we co-expressed Flag-LSD1 and HA-USP28 in HEK293 cells."
24075993
sparser
"The interaction between LSD1 and USP28 is specific, as LSD1 could not interact with USP7 and USP25 under similar conditions ( xref )."
24075993
sparser
"Our results are in accordance with an older study that showed that the USP28–LSD1 axis controlled CSC-like properties in human breast cancer [ xref ]."
31627418
sparser
"To identify the region that is responsible for the LSD1 interaction with USP28, we generated LSD1 domain-deletion mutants and co-expressed them with USP28 in HEK293 cells."
24075993
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"USP28 can interact with and stabilize LSD1."
29415985
sparser
"These results indicate that the AO domain is required for the interaction of LSD1 with USP28."
24075993