IndraLab

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Stavudine inhibits NLRP3. 6 / 6
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"On the other hand, stavudine (D4T) downregulates the NLRP3 inflammasome and stimulates autophagy-mediated Abeta-clearing in a THP-1-derived macrophages."
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"For example, benzylisothiocyanate (126), stavudine (127), and artemisinin (128) all have shown therapeutic effects on AD mice by inhibiting NLRP3 activation.5.3 Regulation of phenotypic variations in microglia."
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"A great achievement was reached when a potent diarylsulfonylurea compound MCC950 (also termed as CRID3, CP-456773), endowed with NLRP3 selectivity, showed therapeutic improvement in several preclinical models such as experimental autoimmune encephalomyelitis, such as AD and PD [229-232], nevertheless it failed in clinical trials because of off-target toxicity.In the search for new inhibitors Stavudine (d4T), acting as an inhibitor of nucleoside reverse transcriptase, has been published recently to downregulate NLRP3 activation in AD [233]."
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"Stavudine "Interferes" via alpha-7nAChR to Inhibit NLRP3 in (LPS+Amyloid-Beta) Stimulated PBMC of AD Patients."
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"MCC950 and stavudine reduce NLRP3 activation and may contribute to the blockade of the IL-1β pathway [ 94 , 95 ]."
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"Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-beta Autophagy."
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