IndraLab

Statements

CASP8 inhibits USP28. 7 / 7
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"Furthermore, Caspase-8 cleaves and inactivates USP28 to overcome the p53-dependent G2/M checkpoint in cancer cells [18]."
| PMC
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"Similarly, USP28 can be cleaved and inactivated by caspase-8, preventing USP28 from deubiquitinating and stabilizing p53, thereby overriding the p53-dependent G2/M cell cycle checkpoint and eventually leading to treatment resistance [113]."
36694209
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"Thus, nuclear caspase-8 cleaves and thereby inactivates ubiquitin-specific peptidase 28 (USP28), the protein which stabilizes the wild-type p53 protein."
34333527
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"We further provide evidence that tumor cells expressing high and nuclear levels of caspase-8 have defective p53-dependent apoptosis because caspase-8 cleaves and inactivates USP28 in cells with delayed or compromised mitosis ( xref )."
31982308
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"Furthermore, Caspase-8 cleaves and inactivates USP28 to overcome the p53-dependent G2/M checkpoint in cancer cells [ xref ]."
| PMC
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"In the nucleus, caspase-8 cleaves and inactivates the ubiquitin specific peptidase 28 (USP28), preventing USP28 from de-ubiquitinating and stabilizing wildtype p53."
| PMC
reach
"In the nucleus, caspase-8 cleaves and inactivates the ubiquitin specific peptidase 28 (USP28), preventing USP28 from de-ubiquitinating and stabilizing wildtype p53."
31982308