IndraLab

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"The bacterial counts in feces, cecum, liver and spleen of the Vil-Cre;Otud4 mice were also significantly reduced compared to Otud4 mice (Fig. 3E), indicating that OTUD4 promotes bacterial infection in vivo."
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"Taken together, our results indicate that OTUD4 in IECs promotes bacterial infection by inhibiting the expression of AMPs.2.5 OTUD4 in Paneth cells promotes intestinal inflammation and bacterial infection."
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"Together, these results indicate that OTUD4 deficiency in IECs results in resistance to dysregulation of microbiota in the gut after DSS treatment.2.4 Depletion of OTUD4 in IECs inhibits bacterial infection in the gut."
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