IndraLab

Statements

USP37 activates polyubiquitin chains. 2 / 2
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"The DUB USP37 directly regulates S-phase entry through antagonising activity of the APC/C CDH1 in G 1 by removing polyubiquitin chains to stabilise CCNA [XREF_BIBR]."
28900014
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"Meanwhile, USP37 is phosphorylated and activated by CDK2, promoting the removal of polyubiquitin chains from ERK1/2 and resulting in the stabilization of ERK1/2.USP37 promotes cancer cell growth via ERK1/2 in vitro and in vivo."
37955924