IndraLab

Statements

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"Additionally, chloroquine and hydroxychloroquine inhibit the Toll like receptor (TLR) pathway; the TLR pathway is involved in pro inflammatory cytokine signaling [XREF_BIBR]."
| PMC
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"Chloroquine and hydroxychloroquine also reduce Toll-like receptor signaling, leading to both the direct and indirect inhibition of the immune system [10] ."
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"In addition to its suppressive effects on viral replication, hydroxychloroquine inhibits Toll-like receptor 7/9–dependent inflammatory responses."
32624257
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"By influencing several cellular pathways through different mechanisms, CQ and HCQ inhibit multiple endolysosomal functions, including autophagy, as well as endosomal Toll like receptor activation and calcium signalling."
32715647
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"Hydroxychloroquine inhibits Toll like receptor pathways and minimizes flare, treats skin disease, and decreases the rate of autoantibody production [XREF_BIBR, XREF_BIBR,]."
27747587
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"Hydroxychloroquine, which inhibits Toll like receptor activation, has anecdotally been helpful as an adjunctive agent and has been shown to improve cutaneous and renal disease activity and prevent disease damage in lupus 107."
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