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P5091 activates CASP3. 3 / 3
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"Treatment of MM.1 S and RPMI-8226 cells with P5091 induces caspase-3 cleavage, as well as activates caspase-9 and casapse-8 apoptotic pathways (XREF_SUPPLEMENTARY)."
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"Further, P5091 treatment also triggered cleavage of PARP and caspase-3 in a dose-dependent manner (Figure 2D)."
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"As shown in Fig. 6 D–G, exposure of HCT116, SW480 and Caco-2 cells with P5091 induced caspase-3 cleavage and activated the caspase-8 and caspase-9 apoptotic pathways, associated with the cleavage of p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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