IndraLab

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USP22 binds AP4. 4 / 4
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"In addition, USP22 binds to the promoter region of AP4 to activate its transcription."
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"Consistent with the above results, ChIP analysis revealed that USP22 binds the promoter region of AP4 (Figure xref )."
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"We also found that USP22 binds to the promoter region of AP4 to mediate its transcription and thus induce CRC cell EMT."
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"Additionally, assessment of CRC clinicopathological characteristics demonstrated that USP22 and AP4 expression levels were significantly associated with pT classification, pM classification, AJCC stage and tumor markers used as prognostic indicators of postoperative recurrence and metastasis in CRC, including CEA and CA199."
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