IndraLab

Statements

STAMBP activates NLRP7. 4 / 4
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"These results are consistent with prior data demonstrating NALP7 degradation at the lysosome and STAMBP rescue of NALP7."
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"Our findings that NALP7 abundance is modulated by the ESCRT-0 complex protein STAM and the DUB STAMBP suggest that NALP7 may similarly function at the early endosome and that, furthermore, NALP7 is processed through the endosomal pathway to the lysosome for degradation."
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"Our group previously demonstrated a functional relationship between STAMBP and another inflammasome protein NLRP7 , whereby STAMBP knockdown enhanced NLRP7 degradation and decreased IL-1beta release in differentiated THP-1 macrophages ( 20 ) ."
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"We hypothesized that targeting of STAMBP DUB activity to destabilize NALP7 will decrease NALP7 inflammasome activity, namely secretion of mature IL-1beta."
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