IndraLab

Statements

Ubiquitin inhibits USP7. 8 / 8
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"A recent publication demonstrated that a ubiquitin variant, engineered to bind tightly to USP7, inhibits USP7 selectively ( K D , 56 nM)."
23684893
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"Here we report PROTACs based on a ubiquitin-specific protease 7 (USP7) inhibitor scaffold to degrade USP7."
35852517
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"Our result indicated the promotion of TRIP12 expression by TSPY1, providing a clue for investigating the potential mechanism underlying ubiquitin mediated degradation of USP7 in future studies."
29748603
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"Moreover, our experiments showed that TSPY1 could decrease the p53 level by facilitating ubiquitin mediated USP7 degradation."
29748603
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"A ubiquitin variant expressed in human tumor cell lines binds and inhibits endogenous USP7, thereby enhancing Mdm2 proteasomal turnover and stabilizing p53."
23178935
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"Another promising approach to stabilizing p53 in cancer cells consists of promoting the MDM2 proteasomal degradation through the Ub variant (UbV)-mediated inhibition of USP7 and USP2a deubiquitinases, known to be involved in stabilizing MDM2."
38201233
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"TSPY1 induces ubiquitin dependent degradation of USP7."
29748603
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"Because USP7 could stabilize most of the proteins degraded in extract treated with UbVS and ubiquitin, we tested if inactivation of USP7 using the specific inhibitor XL-188 was sufficient to induce degradation of the substrates that we identified."
33417828