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USP4 decreases the amount of TRAF6. 2 / 2
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"Moreover, although USP4 downregulation can decrease the expression of TRAF6, knockdown TRAF6 expression did not affect USP4 protein level which implied a unidirectional action between USP4 and TRAF6 ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"USP4 silencing in LPS induced activation of microglia promoted the expression of p-p65 and TRAF6 and the secretion of TNF-alpha and IL-1beta."