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UCHL1 activates autophagy. 4 / 6
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"Furthermore, in the context of a-syn-induced pathology, modulation of UCH-L1 activity could serve as a therapeutic tool to enhance the autophagy pathway and induce clearance of the observed accumulated and aggregated a-syn species in the PD brain."
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"It has been proposed that modulation of UCHL1 activity may serve as a therapeutic tool to enhance the autophagy pathway and induce clearance of aggregated αSYN (63)."
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"In conclusion, our results suggest that cPKCgamma activation alleviates ischaemic injuries of mice and cortical neurons through inhibiting UCHL1 expression, which may negatively regulate autophagy through ERK-mTOR pathway."
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"UCHL1 enhances autophagy in motor neurons of the patients with ALS [171] ."
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