IndraLab

Statements

Rottlerin activates KCNMA1. 5 / 5
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"Rotterlin and mallotoxin activates BK channel activation only within BKgamma1 positive (LRRC26) found in parotid cells (XREF_FIG) [XREF_BIBR]."
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"By activating the BK channel, rottlerin stimulates a massive outflow of current in heart and nervous tissue XREF_BIBR."
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"Consistent with these results, the BK channel activator rottlerin showed a marked antifibrotic effect, both in vitro and in vivo."
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"Accordingly, rottlerin-induced BK channel activation did not affect the proliferation of LX2 cells (Figure 3D)."
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"In addition to NS1619 and Cym04, several other compounds comprising a diverse range of chemical classes are known BK channel activators, including the natural products mallotoxin and dehydroxysoyasaponin, and synthetic compounds such as the aryloxindole derivative BMS-204352 and the biarylthiourea derivative NS11021."
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