IndraLab

Statements

BAP1 inhibits Cell Survival. 8 / 9
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"These results indicate that the reduction in colon cancer cell viability induced by BAP1 depletion was attributed mainly to increased apoptosis."
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"Furthermore, our results reveled that BaP1 reduced cell survival and cell motility, two desirable properties for an anticancer drug.Interestingly, when we treated RKO cells with higher doses of BaP1, 2 × IC and 4 × IC , concentrations that still have a reduced inhibitory effect in the noncancerous colon cell line NCM460, we observed well-established and correlated phenotypes."
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"Crucially, concomitant BAP1 and HDAC2 depletion did not additively reduce cell viability in the presence of vorinostat."
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"We found that BaP1 is selective for CRC cells and reduces cell proliferation , cell survival , and cell migration ."
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"Overexpression of BAP1 significantly reduced cell viability (Figure 9A) and promoted cell apoptosis (Figure 9B), while CsA reversed these results."
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"BAP1 suppresses cell viability and growth."
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"BaP1 Inhibits Proliferation, Reduces Cell Survival and Motility, and Leads to ROS Generation in RKO Cells."
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"In summary, it seems that loss of BAP1 foster genomic instability in tumor pathogenesis, however, the activity of BAP1 promotes tumor cell survival and contributes to therapeutic resistance during irradiation."
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