IndraLab

Statements

USP29 decreases the amount of IFNB1. 3 / 3
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"Interestingly, we found that knockdown of USP29 significantly impaired various cytoplasmic DNA induced expression of IFNB, TNF, and IP10 but had little effect on cGAMP induced expression of IFNB, TNF, and IP10."
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"Accordingly, USP29 enhanced ORF9b-mediated IFN-β inhibition, while USP29 alone did not affect IFN-β mRNA levels (Fig. 6D)."
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"Knockdown of USP29 by these two shRNAs significantly inhibited HSV-1-induced expression of IFNB, TNF, IL6, and IP10 in THP-1 cells (The # 2 shRNA was used for the following experiments and similar results were observed with # 1 shRNA)."
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