IndraLab

Statements

IRF3 binds OTUD6B. 6 / 8
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"Moreover, endogenous OTUD6B and IRF3 constitutively interacted in 293T cells ( xref )."
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"Through immunoprecipitation experiments, we found that OTUD6B interacted with the IRF3 C-terminal domain (IRF3-ΔN), and not with the N-terminal domain (IRF3-ΔC), suggesting that OTUD6B catalyzing site(s) are distributed in the C-terminal of IRF3 ( xref )."
37650650
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"Mechanically, we found that OTUD6B interacts with IRF3 and directly hydrolyzes both the lysine 11 (K11)- and the lysine 33 (K33)-linked polyubiquitin chain, but only K33-linked polyubiquitin at Lys315 of IRF3 is responsible for IRF3 proteasome degradation."
37650650
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"The OTUD6B interacts with IRF3 and cleaves K11- and K33-linked ubiquitin chains of IRF3."
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"OTUD6B interacted with IRF3."
37650650
sparser
"Immunoprecipitation experiments confirmed that OTUD6B interacted with IRF3 and not with RIG-I, MAVS, and TBK1 ( xref ), and similar results were obtained using reverse immunoprecipitation ( xref )."
37650650