IndraLab

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OTUD7B ubiquitinates SQSTM1. 3 / 3
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"With respect to viral infection, in vitro studies revealed that OTUD7b impairs innate anti-viral immunity in macrophages by deubiquitinating SQSTM1/p62 during vesicular stomatitis virus infection [58]."
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"Moreover, OTUD7B negatively regulates antiviral immunity by deubiquitinating p62, promoting IRF3 autophagic degradation and balancing type I interferon signaling during viral infection [16]."
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"With respect to viral infection, in vitro studies revealed that OTUD7b impairs innate anti-viral immunity in macrophages by deubiquitinating SQSTM1/p62 during vesicular stomatitis virus infection [58]."
37516734