IndraLab

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USP18 inhibits pyroptosis. 8 / 8
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"Collectively, these findings suggest that USP18 promotes GSDMD degradation through ubiquitination of GSDMD at K168, thereby impairing its subsequent pyroptosis."
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"USP18 depletion induces both GSDMD and GSDME-dependent pyroptosis upon IFN treatment."
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"The mechanism by which ubiquitin-specific protease 18 (USP18) (enzyme commission: 3.4.19.12) inhibition in cancer promotes cell pyroptosis via the induction of interferon (IFN)-stimulated genes has been recently demonstrated."
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"Since pyroptosis was induced by USP18 depletion but has not been well described upon interferon treatment, and Caspase-3-mediated GSDME cleavage is not involved in canonical inflammasome-Caspase-1-mediated GSDMD cleavage, we hypothesized that atypical ISGs may contribute to cleaved GSDME-mediated pyroptosis."
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"USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D."
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"We next attempted to investigate the inhibitory function of USP18 in GSDMD-mediated pyroptosis through its interaction with GSDMD."
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"USP18 suppression could induce cancer cell GSDME-dependent pyroptosis and suppress leukemogenesis via upregulating PLK2, an atypical ISG [24] (Fig. 2A)."
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"USP18 depletion induces pyroptosis, which is dependent on the NLRP3 inflammasome-Caspase-1-GSDMD and Caspase-3-GSDME pathways."
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