IndraLab

Statements

USP20 activates YAP1. 3 / 3
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"Based on the above results, we investigated whether USP20-mediated YAP1 stabilization was mediated by the direct deubiquitination of USP20."
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"Our results indicated that USP20 deubiquitinated and increased the protein stability of YAP1 by removing the K48-linked polyubiquitin chains from YAP1."
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"Through direct interaction with YAP1, USP20 modulates the activity and stability of YAP1 to exert its biological functions via the transition between activated or deactivated Hippo.Combination therapy has only slightly improved the overall survival of patients with BC."
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