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USP8 decreases the amount of TLR4. 2 / 2
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"We confirmed that the expression of TLR4 was elevated in LPS-induced mice (0.68 ± 0.09) compared to control and saline groups, whereas USP8 pre-treatment significantly reduced TLR4 expression (control[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, in a previous study, USP8 increased NRDP1 levels, potently downregulated MyD88 and TLR4 levels, and blocked inhibitor of NF-κB kinase subunit β and IκBα phosphorylation, thus decreasing p65 nuclear translocation, resulting in and inhibition of NF-κB signaling pathway activation in LPS-induced mice (12)."
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