IndraLab

Statements


USP7 increases the amount of FOXP3. 4 / 4
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"USP7 Mediated Foxp3 Deubiquitination Results in Increased Foxp3 Protein Expression."

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"Foxp3 K22xR protein amounts were not increased by the cotransfection of USP7, indicating that USP7 stabilizes Foxp3 expression by direct deubiquitination."

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"By contrast, overexpressing USP7 in T reg cells increases FOXP3 protein levels and augments T reg cell activity 104."

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"To determine whether USP7 mediated deubiquitination results in increased Foxp3 protein amounts, we assessed Foxp3 expression in HEK 293T cells that were cotransfected with Foxp3 and USP7."