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USP10 activates PIK3C3. 2 / 2
| 2

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"We propose that USP10 and USP13 mediate the deubiqutination of Vps34 complexes to regulate the levels of class III PI3 kinase."

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"Interestingly, Spautin-1-mediated specific and potent inhibition of deubiquitinating activity of USP10 and USP13 was shown to promote proteasomal degradation of PIK3C3 and thereby inhibit autophagy [179]."