IndraLab

Statements

Acrylamide inhibits NLRP3. 19 / 19
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"AA Inactivates the S.T-Induced NLRP3 Inflammasome by Upregulating TVX1."
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"Administration of AA significantly attenuated hepatic histopathological damage, global inflammatory level, apoptotic signaling level, as well as NLRP3 inflammasome activation."
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"Furthermore, GW9662 reversed AA mediated suppression of NLRP3 signaling, as evidenced by increase in mRNA levels of NLRP3 and IL-1beta, protein levels of NLRP3 and pro-IL-1beta, formation of NLRP3, ASC, pro, and caspase-1 complex as well as production of cleaved capase-1 p10 and mature IL-1beta."
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"Emerging evidence demonstrates that AA inhibits NLRP3 inflammasome assembling and caspase-1 inhibition in macrophage [XREF_BIBR]."
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"In particular, AA induced the appearance of higher molecular weight of NLRP3 and decreased NLRP3 protein in the cell lysates.Recent studies have found that G5, the deubiquitinase inhibitor, critically[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overall, BOT-4-one is another interesting covalent inhibitor in the arsenal of NLRP3-blocking molecules.WP1066 ( Fig. 16 a) is an acrylamide derivative that was originally synthesised and patented as [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, AA suppressed the activation of the NLRP3 inflammasome."
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"Therefore, AA attenuated NLRP3 signaling both at expression level and assembly level."
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"AA decreases NLRP3 inflammasome activation in ischemic liver."
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"These results demonstrate that AA can suppress the activation of NLRP3 inflammation in BV2 microglia cells."
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"PPARgamma/ROS/MAPK and PPARgamma/ROS/NF-kappaB involve in AA mediated suppression of NLRP3 inflammasome."
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"Inhibition of PPARgamma abolishes the protective effects of AA against I/R induced inflammatory injury and NLRP3 inflammasome activation."
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"Compound 5 was further modified using acrylamide functionality to develop 2-(2-chlorobenzyl)-N-(4-sulfamoylphenethyl) acrylamide (INF58), which inhibited the NLRP3 ATPase activity with an IC value of 74 μM [160]."
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"This screening allowed the identification of 14, 2-(2-chlorobenzyl)-N-(4-sulfamoylphenethyl) acrylamide, which was able to concentration-dependently inhibit NLRP3 ATPase with an IC50 value of 74mum."
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"In this study, we demonstrated that AP, a fat-soluble form of AA widely used in cosmetics, food and pharmaceutical industries, effectively inhibits NLRP3 inflammasome-driven inflammation in vivo and i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Administration of AA significantly suppressed NLRP3 activation and global inflammatory levels in the ischemic liver."
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"In addition, AA could suppress other inflammasomes and LPS-induced priming process at the concentrations of which AA inhibited NLRP3 inflammasome."
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"These findings were also confirmed by in vitro experiments in which AA pretreatment suppressed NLRP3 activation in LPS/H 2 O 2 -challenged KCs or RAW264.7 cells."
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"In the present study, AA pretreatment reduced S.T-induced activation of the NF-κB pathway and the NLRP3 inflammasome, further demonstrating the anti-inflammatory effect of AA.Our sequencing data showed that lncRNA TVX1 expression was decreased upon S.T infection and increased upon AA pretreatment."
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