IndraLab

Statements


5 | 4

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"9,23 Indeed, MDL 28,170 inhibited cathepsin B and cathepsin L by nearly 100% at 0.2 μM concentration."

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"For this, we infected LA-N-5 cells in the presence of either MDL-28170 (chemical inhibitor of cathepsin B [Fig. 4C]) or Z-FA-FMK (chemical inhibitor of both cathepsin B and L [Fig. 4D])."

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"MDL-28170 at the concentration we used may also inhibit cathepsin B XREF_BIBR."

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"For example, although MDL-28170 is considered relatively specific for calpain, cathepsin B, a lysosomal cysteine protease, is also inhibited by MDL-28170 at a similar K i of 12–24 nM [44] ."