IndraLab

Statements

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"These results indicate that BAP1 inactivation in MPM correlates with an increase in DCs and inflammatory macrophages and a decrease in immunosuppressive MDSCs, further supporting the notion that BAP1 deficiency promotes the immune response in MPM."
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"We fortuitously found that deletion of Bap1 in cancer cells can trigger an anti-tumor immunity, regardless of the expression of PD-L1."
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"Loss of histone deubiquitinase Bap1 triggers anti-tumor immunity."
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"We found that loss of histone deubiquitinase Bap1 in cancer cells activates a cDC1-CD8 + T cell-dependent anti-tumor immunity."
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"Consequently, BAP1 loss may promote metastasis at least in part by allowing tumor cells to evade the patient’s immune response."
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"To understand how the loss of Bap1 activates anti-tumor immunity, we conducted a comparison of the immune subsets present in the tumor microenvironment of Bap1-KO and control WT (MC38-Cas9) tumors."
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