IndraLab

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Formic acid inhibits NLRP3. 12 / 12
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"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."
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"As HDAC inhibitors, SCFAs block the activity of the NLRP3 inflammasome and reduce autophagy, thereby alleviating LPS injury in the intestinal barrier.Studies have found that autophagy can directly affect the transcription, processing, and secretion of some cytokines."
31777004
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"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."
29475132
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"The results of the present study indicated that three SCFAs inhibited ox-LDL-induced cell inflammatory injury by blocking the NLRP3/Caspase-1 pathway, thereby improving cellular metabolism."
36557935
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"It was proved that the Short Chain Fatty Acids (SCFAs) b-hydroxybutyrate (BHB) and acetoacetate, both elevated during starvation, inhibit the NLRP3 inflammasome."
34104708
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"For example, butyrate, a SCFAs, is associated with reduced levels of TNF-α, IL-6 and suppressed activation of the NLRP3 inflammasome via GPR109A (20)."
34867823
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"Based on the aforementioned results, we speculated that QFY may exert its protective effect against bacterial pneumonia-induced lung injury by targeting gut microbiota to stimulate production of SCFAs that inhibit the NF-kB/NLRP3 axis."
34950611
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"Next, the mechanism by which SCFA mediates NLRP3 suppression is analyzed."
35844801
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"It was proved that the Short Chain Fatty Acids (SCFAs) β-hydroxybutyrate (BHB) and acetoacetate, both elevated during starvation, inhibit the NLRP3 inflammasome."
34104708
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"Collectively, these data indicated that SCFA regulates the activation of NLRP3 inflammasome via GPR43 and CaMKII, which preliminarily revealed the potential mechanism of SCFA-mediated NLRP3 inflammasome attenuation."
35844801
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"XREF_BIBR SCFA treatment increases in paracellular transport, maintenance of ZO-1 and OCLN proteins, inhibition of NLRP3 (NOD-, LRR-, and pyrin domain containing protein 3) inflammasome activation, and autophagy."
33610769
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"It was proved that the Short Chain Fatty Acids (SCFAs) beta-hydroxybutyrate (BHB) and acetoacetate, both elevated during starvation, inhibit the NLRP3 inflammasome."
34104708