IndraLab

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Formic acid inhibits NLRP3. 29 / 29
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"Here, in ox-LDL-stimulated THP-1 cells, our data are the first to confirm that three SCFAs suppress inflammation events via inhibiting NLRP3 activation."
36557935
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"The objective of this study is to analyze whether SCFAs can attenuate lung inflammation and tissue remodeling in murine neutrophilic asthma and NLRP3 contribution to this endotype."
38329636
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"However, FMT and SCFA administration markedly downregulated NLRP3 (Fig. 8A, B), indicating that this treatment strategy may partly decrease differentiation of pathogenic Th17 cells by reducing the production of IL-1β."
36567333
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"Further, B. fragilis helps prevent chronic inflammation and produces short-chain fatty acids (SCFAs), negatively regulating the NLRP3 inflammatory pathway [142]."
38785512
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"Previous evidence demonstrated that SCFAs act as energy substances and HDAC inhibitors to repair the dysregulated intestinal barrier and suppress the NLRP3 inflammasome [62]."
36558410
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"It was reported that β-hydroxybutyrate (BHB) rather than structurally related SCFAs, butyrate, and acetate, suppressed the activation of the NLRP3 inflammasome in intestinal inflammation [ 52 ]."
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"Next, the mechanism by which SCFA mediates NLRP3 suppression is analyzed."
35844801
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"Therefore, we hypothesized that SCFAs prevent 5-FU-induced intestinal mucosal inflammation by inhibiting the activation of NLRP3 inflammasomes through the regulation of the glycerolphospholipid and sphingolipid pathways."
36677551
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"59 Some studies reported that β-hydroxybutyrate rather than the structurally related SCFAs butyrate and acetate suppressed the activation of the NLRP3 inflammasome in intestinal inflammation."
36371983
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"Collectively, these data indicated that SCFA regulates the activation of NLRP3 inflammasome via GPR43 and CaMKII, which preliminarily revealed the potential mechanism of SCFA-mediated NLRP3 inflammasome attenuation."
35844801
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"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."
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"Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, produced by the fermentation of dietary fibers by intestinal bacteria, have been shown to inhibit the HMGB1/NLRP3 pathway."
40213692
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"The results of the present study indicated that three SCFAs inhibited ox-LDL-induced cell inflammatory injury by blocking the NLRP3/Caspase-1 pathway, thereby improving cellular metabolism."
36557935
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"Previous reports have shown that SCFAs could decrease inflammation by modulating p38 MAPK, NLRP3, and MEK–ERK signaling pathways (Segain et al., 2000; Park et al., 2007; Yonezawa et al., 2007; Kobayashi et al., 2017)."
35652042
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"It was proved that the Short Chain Fatty Acids (SCFAs) beta-hydroxybutyrate (BHB) and acetoacetate, both elevated during starvation, inhibit the NLRP3 inflammasome."
34104708
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"Furthermore, SCFAs attenuate NLRP3 inflammasome activation through the GPR43 signaling pathway and ultimately induce NLRP3 degradation through the autophagy pathway, thereby reducing the occurrence of atrial fibrillation."
38073096
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"Feng et al. (56) and other studies have shown that SCFAs inhibit the activation of NLRP3 inflammasome bodies and protect the function of the intestinal barrier."
35191381
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"The appropriate concentrations of SCFAs reduced the production of IL-1β by preventing the NLRP3 pathway and regulating the activity of Treg cells by activating GCR43 [41]."
37762155
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"SCFAs can reduce the NLRP3 inflammasome through their protective effect on the intestinal barrier."
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"In addition, this study also found that the three kinds of SCFAs could also inhibit the activation of NLRP3 inflammasome in Caco-2 cells and inhibit the expression of inflammatory cytokines IL-18."
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"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."
29475132
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"Based on the aforementioned results, we speculated that QFY may exert its protective effect against bacterial pneumonia-induced lung injury by targeting gut microbiota to stimulate production of SCFAs that inhibit the NF-kB/NLRP3 axis."
34950611
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"Additionally, previous research has demonstrated that administering probiotics and short-chain fatty acids (SCFAs), key probiotic metabolites, reduces NLRP3 signaling pathway activity in an IgAN mouse model."
40328979
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"As HDAC inhibitors, SCFAs block the activity of the NLRP3 inflammasome and reduce autophagy, thereby alleviating LPS injury in the intestinal barrier."
31777004
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"For example, butyrate, a SCFAs, is associated with reduced levels of TNF-α, IL-6 and suppressed activation of the NLRP3 inflammasome via GPR109A (20)."
34867823
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"In vitro and in vivo studies have shown that SCFAs can ameliorate the LPS-induced intestinal barrier disruption by suppressing NLRP3 inflammasome and autophagy by inhibiting ROS production (Feng et al., 2018)."
37469598
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"Although the authors of this paper did not directly examine if the reduced NLRP3 expression was associated with the increase of SCFAs in the colon, many previous studies had shown that various SCFAs such as butyrate could suppress the activation of the NLRP3 inflammasome [82]."
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"For example, SCFA, particularly butyrate, can limit the activation of NF-κB and NLRP3 pathways, which were involved in the pathogenesis of mastitis and responsible for the production of inflammatory cytokine [5,39,40]."
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"XREF_BIBR SCFA treatment increases in paracellular transport, maintenance of ZO-1 and OCLN proteins, inhibition of NLRP3 (NOD-, LRR-, and pyrin domain containing protein 3) inflammasome activation, and autophagy."
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