IndraLab

Statements

OTUB1 activates CD274. 6 / 6
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"OTUB1 deficiency leads to HCC cells to become more sensitive to T cell mediated cytotoxicity, inhibits tumor growth and enhances anti-tumor immunity in mice by regulating PD-L1 79, 80.When PD-1 binds to ligand, it inhibits T cell response and reduces T cell secretion of IFN-γ 61."
35541908
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"Here, we report that the deubiquitinase OTUB1 positively regulates PD-L1 stability and mediates cancer immune responses through the PD-1 and PD-L1 axis."
33328570
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"OTUB1 deubiquitinated and thus prevented the degradation of PD-L1."
34416901
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"Knockdown of USP22 or OTUB1 only significantly reduces PD-L1 abundance in NCI-H358 cells but not in SK-MES-1 cells."
38167274
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"Indeed, OTUB1 promotes cancer cell immunosuppression by targeting PD-L1 in different cancer cells ( Zhu et al., 2020 )."
33609777
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"OTUB1 upregulation prevents PD-L1 degradation via removing ubiquitin chains, and ultimately increases resistance to anti-PD-1 immunotherapies and promotes immune evasion."
38075202